Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 550, Issue -, Pages 127-133Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.02.143
Keywords
DNA double-strand breaks (DSBs); MRNIP; Meiotic progression
Categories
Funding
- National Natural Science Foundation of China [81901532, 81901533]
- Natural Science Foundation of Jiangsu Province [BK20190188]
- Suzhou Science and Technology Development Plan [SYSD2019208]
- Suzhou Introduced Project of Clinical Medical Expert Team [SZYJTD201708]
- Suzhou Key Laboratory of Male Reproduction Research [SZS201718]
- Open Fund of State Key Laboratory of Reproductive Medicine of Nanjing Medical University [SKLRMK202010]
- Open Fund of NHC Key Laboratory of Birth Defects and Reproductive Health (Chongqing Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute) [2019-syskfkt-0001]
- Project of Maternal and Child Health of Jiangsu Province [F201913]
- Zhenjiang Social Development [SH2019028]
Ask authors/readers for more resources
Given the importance of the MRN complex in HR, this study identifies MRNIP as a novel HR factor crucial for the expression of the MRN complex and loading of recombinases, thus promoting meiotic progression.
Meiotic homologous recombination (HR) initiates with the programmed generation of DNA double strand breaks (DSBs), which result in the exchange of genetic information and genome diversity. This process requires the tight cooperation of the MRE11-RAD50-NBS1 (MRN) complex to promote DSB formation and DNA end resection. However, the mechanism regulating MRN complex remains to be explored. In the present study, we report that MRN-interacting protein, MRNIP, is a novel factor for HR and is crucial for the expression of the MRN complex and loading of recombinases DMC1/RAD51. Knockout of Mrnip in mice led to aberrant synapsis, impaired HR, and male subfertility. In conclusion, MRNIP is a novel HR factor that probably promotes meiotic progression through the MRN complex. ? 2021 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
