Journal
BRAIN IMAGING AND BEHAVIOR
Volume 10, Issue 3, Pages 920-939Publisher
SPRINGER
DOI: 10.1007/s11682-015-9457-6
Keywords
Anhedonia; Activation likelihood estimation (ALE); Meta-analysis; Transdiagnostic; Major depressive disorder; Schizophrenia
Categories
Funding
- National Natural Science Foundation of China [30700236, 61473221]
- Program for New Century Excellent Talents in University of China [NCET-12-0557]
- Humanities and social science research project of Ministry of education in China [13YJA190015]
- National Institutes of Health [R01MH094594, K23MH097786]
Ask authors/readers for more resources
Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between MDD and SZ, which supported a transdiagnostic approach. Therefore, we used activation likelihood estimation (ALE) meta-analysis of functional magnetic resonance imaging studies in MDD and SZ to examine the neural bases of three subdomains of anhedonia: consummatory anhedonia, anticipatory anhedonia and emotional processing. ALE analysis focused specifically on MDD or SZ was used later to dissociate specific anhedonia-related neurobiological impairments from potential disease general impairments. ALE results revealed that consummatory anhedonia was associated with decreased activation in ventral basal ganglia areas, while anticipatory anhedonia was associated with more substrates in frontal-striatal networks except the ventral striatum, which included the dorsal anterior cingulate, middle frontal gyrus and medial frontal gyrus. MDD and SZ patients showed similar neurobiological impairments in anticipatory and consummatory anhedonia, but differences in the emotional experience task, which may also involve affective/mood general processing. These results support that anhedonia is characterized by alterations in reward processing and relies on frontal-striatal brain circuitry. The transdiagnostic approach is a promising way to reveal the overall neurobiological framework that contributes to anhedonia and could help to improve targeted treatment strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available