Overview of fertility sparing treatments for cervical cancer

Until the late 1980s, the mainstay of treatment for cervical cancer has been either hysterectomy or radiotherapy. From the mid to late 1990s, surgical treatments have been focussed more on sparing fertility by preserving the corpus of the womb with trachelectomy or even conserving part of the cervical stroma with a cone biopsy. In carefully selected cases, less radical treatment that preserves the uterus has been considered safe. However, these approaches can be associated with specific operative and obstetric complications such as stitch ulceration, cervical stenosis, late miscarriage, and premature labour. Most guidelines agree that the management of such patients should be centralised in a unit with specialist gynaecological oncology, radiology, and histopathology services supported by specialist cancer nurses. (c) 2021 Published by Elsevier Ltd.

Automated summary

The mainstay of treatment for cervical cancer used to be hysterectomy or radiotherapy until the late 1980s. However, surgical treatments that focus on sparing fertility have become more common since the mid to late 1990s, but they can be associated with specific operative and obstetric complications. Most guidelines recommend centralizing the management of such patients in a unit with specialist services.