Autophagosome content profiling reveals receptor-specific cargo candidates

Summary: The study investigates the formation of protein aggregates in fed conditions due to autophagy deficiency and the contribution of selective autophagy pathways to cellular proteostasis. Different receptors and substrates of aggrephagy are identified, with a systematic mapping of the autophagic degradome targeted by UBD-containing receptors under basal and proteostasis-challenging conditions.