Journal
AUTOPHAGY
Volume 17, Issue 5, Pages 1063-1064Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2021.1905974
Keywords
ATXN3; autophagy initiation; BECN1; Ptdins3K; VCP
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Funding
- National Institute of General Medical Sciences [GM131919]
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VCP, a conserved ATPase, regulates autophagy initiation by stabilizing BECN1 and enhancing phosphati-dylinositol 3-kinase (PtdIns3K) complex assembly, in addition to its roles in autophagosome maturation.
VCP, a conserved ATPase, is involved in several cellular processes, and mutations in this protein are associated with various diseases. VCP also plays a role in autophagosome maturation. However, because a deficiency in autophagosome maturation presents a readily observable phenotype, other roles of VCP in autophagy regulation, in particular in the initial steps of autophagosome formation, may have been overlooked. In a recently published paper, using small-molecule inhibitors, Hill et al. showed that VCP regulates autophagy initiation through both stabilization of BECN1 and enhancement of phosphati-dylinositol 3-kinase (PtdIns3K) complex assembly.
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