Journal
AUSTRALASIAN JOURNAL OF DERMATOLOGY
Volume 62, Issue 3, Pages 386-389Publisher
WILEY
DOI: 10.1111/ajd.13617
Keywords
bilateral diffuse uveal melanocytic proliferation; cancer; dermatology; ocular; paraneoplastic syndrome
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Funding
- National Cancer Institute/National Institutes of Health [P30CA008748]
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Bilateral diffuse uveal melanocytic proliferation (B-DUMP) is a rare paraneoplastic syndrome presenting with bilateral visual loss, often associated with lung cancer in males and uro-gynaecological cancer in females. Cutaneous involvement with proliferation of dermal melanocytes may also be seen in these patients.
Bilateral diffuse uveal melanocytic proliferation (B-DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B-DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro-gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B-DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear-cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with `B-DUMP'. Simultaneously, she developed multifocal bilateral bluish-greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B-DUMP be termed 'diffuse integumentary melanocytic proliferation (DIMP)'.
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