Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 44, Issue 3, Pages 281-292Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-021-01321-x
Keywords
Drug resistance; Epithelial-mesenchymal transition; Transcription factor; Snail; Twist1; ZEB1
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2021R1A2C1011196, 2015R1A5A1008958]
- Chung-Ang University
- National Research Foundation of Korea [2021R1A2C1011196] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The complex orchestration of gene expression during the transition of epithelial cells into mesenchymal cells is crucial in cancer development and metastasis. EMT-TFs, as primary regulators of this process, play key roles in metastasis and have been implicated in cancer therapy resistance. This review focuses on three main EMT-TFs - Snail, Twist1, and ZEB1 - and their relationship to drug resistance, as well as possible future approaches targeting EMT-TFs.
The complex orchestration of gene expression that mediates the transition of epithelial cells into mesenchymal cells is implicated in cancer development and metastasis. As the primary regulator of the process, epithelial-mesenchymal transition-regulating transcription factors (EMT-TFs) play key roles in metastasis. They are also highlighted in recent preclinical studies on resistance to cancer therapy. This review describes the role of three main EMT-TFs, including Snail, Twist1, and zinc-finger E homeobox-binding 1 (ZEB1), relating to drug resistance and current possible approaches for future challenges targeting EMT-TFs.
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