Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 48, Issue -, Pages 53-62Publisher
ELSEVIER
DOI: 10.1016/j.etap.2016.10.008
Keywords
Paraquat; Developmental neurotoxicity; Acute toxicity; Motor performance; Cognitive deficiency; Immunochemistry
Ask authors/readers for more resources
In the present work, we investigated developmental toxicity of Paraquat (PQ), from the 1 st or 6th day of mating and throughout the gestation period. We have examined several parameters, including toxicity indices, reproductive performance, sensorimotor development, as well as anxiety and cognitive performance of the offspring. Our results showed that exposure to 20 mg/kg of Paraquat during the first days of pregnancy completely prevents pregnancy in treated mice, but from the 6th day of pregnancy, an alteration in fertility and reproductive parameters was observed. In offspring, the PQ was responsible for an overall delay of innate reflexes and a deficit in motor development. All exposed animals showed a decrease in the level of locomotor activity, increased levels of anxiety-like behavior and pronounced cognitive impairment in adulthood. These results demonstrated that Paraquat led to the onset of many behavioral changes that stem from the impairment of neuronal developmental processes in prenatally exposed mice. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available