Journal
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
Volume 46, Issue 9, Pages 1058-1064Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/apnm-2020-1119
Keywords
facioscapulohumeral muscular dystrophy; muscular dystrophy; resting metabolic rate; metabolism; energy expenditure; nutrition
Categories
Funding
- Friends of FSH Research
- National Institutes of Arthritis and Musculoskeletal and Skin Diseases [R01 AR055685]
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This study found that individuals with FSHD have a 15% lower absolute resting metabolic rate (RMR) compared to controls, but when normalized to lean body mass, no differences were observed. This suggests that the lower levels of lean body mass observed in FSHD patients likely contribute to the lower absolute RMR values.
This study aimed to determine whether resting metabolic rate (RMR) is altered in adults with facioscapulohumeral muscular dystrophy (FSHD). Eleven people with FSHD (51 +/- 12yrs, 2 females) and 11 controls (48 +/- 14 yrs, 2 females) completed 1 visit, including 30-minutes of indirect calorimetry and dual-energy X-ray absorptiometry (DXA) scanning. RMR was calculated from resting oxygen consumption/carbon dioxide production; regional/whole-body fat mass and lean mass were collected from the DXA scan. Absolute RMR was 15% lower in FSHD (p = 0.04); when normalized to regional/local lean mass, no differences in RMR were observed (p > 0.05). Absolute RMR was correlated with total lean mass for all participants combined (p < 0.01, r = 0.70, males only: p < 0.01, r = 0.81) and when analyzed separately (FSHD males: p = 0.001, r = 0.92 and control males: p = 0.004, r = 0.85). Whole-body lean mass was 16% lower in FSHD and leg, arm and appendicular lean mass were lower in FSHD (p < 0.05 for all), though trunk lean mass was not (p = 0.15). Whole-body fat mass was 45% higher in FSHD, with greater leg fat mass (p = 0.01), but not trunk or armfatmass (p > 0.05 for both). When RMR was expressed relative to lean body mass, no differences in RMR were found, indicating that the lower levels of leanmass observed in FSHD patients likely contribute to the lower absolute RMR values. Novelty: RMR is lower among people with FSHD, as compared with controls. The reduced RMR among people with FSHD is due to disease-related loss in muscle mass and likely related to lower physical activity and/or exercise levels.
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