Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 65, Issue 6, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00256-21
Keywords
Talaromyces marneffei; olorofim
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Funding
- Intramural Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Intramural Research Program of the National Institutes of Health, Clinical Center, Department of Laboratory Medicine
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OLOROFIM exhibits the highest antifungal activity against both mold and yeast phases of Talaromyces marneffei isolates.
In vitro antifungal susceptibility profiling of 32 clinical and environmental Talaromyces marneffei isolates recovered from southern China was performed against olorofim and 7 other systemic antifungals, including amphotericin B, 5-flucytosine, posaconazole, voriconazole, caspofungin, and terbinafine, using CLSI methodology. In comparison, olorofim was the most active antifungal agent against both mold and yeast phases of all tested Talaromyces marneffei isolates, exhibiting an MIC range, MIC50, and MIC90 of 0.0005 to 0.002 mu g/ml, 0.0005 mu g/ml, and 0.0005 mu g/ml, respectively.
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