Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 65, Issue 7, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02306-20
Keywords
nontuberculous mycobacteria; Mycobacterium avium complex; Mycobacterium abscessus; Mycobacterium kansasii; oxazolidinone; nontuberculous mycobacteria
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Funding
- LegoChem Biosciences (Daejeon, South Korea)
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI20C0017]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2020R1I1A1A01066970]
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The in vitro activities of oxazolidinone antibiotics were evaluated against clinical nontuberculous mycobacteria isolates, with sutezolid showing the lowest MIC and MBC values for some NTM subtypes. Oxazolidinone antibiotics may be further investigated as a potential treatment for NTM.
We evaluated the in vitro activities of oxazolidinone antibiotics, including linezolid, sutezolid, and delpazolid, against clinical nontuberculous mycobacteria (NTM) isolates. Regardless of macrolide resistance, for Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium kansasii, sutezolid showed the lowest MIC and minimal bactericidal concentration (MBC) values among oxazolidinone antibiotics. However, for Mycobacterium abscessus and Mycobacterium massiliense, the MIC and MBC for all oxazolidinone antibiotics showed similar values. Oxazolidinone antibiotics warrant further investigation as potential treatment for NTM.
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