4.5 Article

The endocrine effects of dietary brominated diphenyl ether-47 exposure, measured across multiple levels of biological organization, in breeding fathead minnows

Journal

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Volume 35, Issue 8, Pages 2048-2057

Publisher

WILEY-BLACKWELL
DOI: 10.1002/etc.3351

Keywords

Polybrominated diphenyl ether 47; Brominated diphenyl ether 47; Reproduction; Gene expression; Fathead minnow

Funding

  1. Texas Christian University Research and Creative Activities Fund
  2. Texas Christian University Biology Department Adkins Fund

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The goal of the present study was to evaluate the reproductive function of fathead minnows (Pimephales promelas) exposed to brominated diphenyl ether-47 (BDE-47) at doses lower than those used in previous studies. This was accomplished by evaluating the impacts of BDE-47 exposures across multiple levels of biological organization. Breeding pairs were exposed to BDE-47 via diet for 21d, during which reproductive success was monitored. At the conclusion of the exposure, fish were euthanized to assess the effects of BDE-47 on sex steroid-related and thyroid-related transcripts, plasma androgen levels, gonadosomatic index (GSI), and secondary sexual characteristics. Several alterations in gene expression were noted including a >2.1-fold decrease in hepatic estrogen receptor (er) and a 2.9-fold decrease in ovarian aromatase (arom). In addition, BDE-47-exposed males experienced increases in deiodinase 2 (dio2) expression in brain tissue (approximate to 1.5-fold) and decreases in hepatic transthyretin (ttr) expression (approximate to 1.4-fold). Together, these gene expression alterations suggest the potential for BDE-47 to disrupt endocrine signaling. There were no significant differences in plasma hormone levels, GSI, secondary sexual characteristics, or reproductive success. Overall, the present study demonstrates that exposure to BDE-47 is capable of altering both sex steroid-related and thyroid-related transcripts but that these observed alterations do not necessarily manifest themselves at higher levels of biological organization for the endpoints selected. Environ Toxicol Chem 2016;35:2048-2057. (c) 2016 SETAC

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