4.1 Review

1921-2021: From insulin discovery to islet transplantation in type 1 diabetes

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Clinical Impact of Residual C-Peptide Secretion in Type 1 Diabetes on Glycemia and Microvascular Complications

Anita Jeyam et al.

Summary: The study found that even minimal residual C-peptide secretion could have clinical benefits in type 1 diabetes. The effects on the risk of hypoglycemic episodes were detectable at lower levels of C-peptide.

DIABETES CARE (2021)

Article Medicine, Research & Experimental

Residual beta cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia

Rose A. Gubitosi-Klug et al.

Summary: The study found that long-term type 1 diabetes mellitus patients may still have residual beta cell function, which is associated with a reduced prevalence of severe hypoglycemia.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Endocrinology & Metabolism

Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial

Matthias von Herrath et al.

Summary: This study aimed to investigate the combination of anti-interleukin-21 antibody and liraglutide for treating type 1 diabetes, and found that this combination therapy could preserve beta-cell function with a better safety profile compared to traditional immunomodulation methods.

LANCET DIABETES & ENDOCRINOLOGY (2021)

Review Urology & Nephrology

Transplant Options for Patients With Diabetes and Advanced Kidney Disease: A Review

Aleksandra Kukla et al.

Summary: Optimal glycemic control and consideration of beta-cell replacement therapy such as pancreas or islet transplantation are important for kidney transplant recipients with diabetes. International variation in offering these options to suitable candidates is influenced by national regulatory policies, pancreas/islet allocation policies, and transplant waiting list dynamics. Early referral, informed decision making, and thorough pretransplant evaluation are crucial for selecting appropriate candidates.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

Review Medicine, General & Internal

Advances in β-cell replacement therapy for the treatment of type 1 diabetes

Marie-Christine Vantyghem et al.

LANCET (2019)