Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 34, Pages 18467-18471Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202104737
Keywords
C-H bond activation; C-N bond formation; copper catalysis; dehydrogenative alkane functionalization; light alkane amidation
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Funding
- MINECO [CTQ2017-82893-C2-1-R]
- Junta de Andalucia [P18-RT-1536]
- PO FEDER 2014-2020 [UHU-1260216]
- Office of Science, of the US Department of Energy [DE-AC02-05CH11231]
- Universidad de Huelva/ CBUA
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This study reports a dehydrogenative coupling reaction to form N-alkyl amides by reacting amides with C1-C4 hydrocarbons, using tBuOOtBu as oxidant and a copper complex as catalyst. The reactions showed good yields in benzene or supercritical carbon dioxide as solvents. Compared to previous studies on larger alkanes, the reactivity in this amination process correlated with bond dissociation energies.
The functionalization of C-H bonds in light alkanes, particularly to form C-N bonds, remains a challenge. We report the dehydrogenative coupling of amides with C1-C4 hydrocarbons to form N-alkyl amide products with tBuOOtBu as oxidant, and a copper complex of a phenanthroline-type ligand as catalyst. The reactions occurred in good yields in benzene or supercritical carbon dioxide as solvents. This strategy allowed for the determination of the relative reactivity of these alkane C-H bonds toward this amination process and showed, in contrast to prior work with larger alkanes, that the reactivity correlated with bond dissociation energies.
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