Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 38, Pages 20606-20626Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202102009
Keywords
analytical methods; continuous manufacturing; flow chemistry; process analytical technology (PAT)
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Process analytical technology (PAT) is a system that helps chemists understand and control manufacturing processes by combining analytical devices and mathematical models to ensure product quality. Continuous manufacturing in industries like pharmaceuticals requires the development of PAT tools suitable for flow reactors, with innovative sampling and analysis methods being essential.
Process analytical technology (PAT) is a system designed to help chemists better understand and control manufacturing processes. PAT systems operate through the combination of analytical devices, reactor control elements, and mathematical models to ensure the quality of the final product through a quality by design (QbD) approach. The expansion of continuous manufacturing in the pharmaceutical and fine-chemical industry requires the development of PAT tools suitable for continuous operation in the environment of flow reactors. This requires innovative approaches to sampling and analysis from flowing media to maintain the integrity of the reactor content and the analyte of interest. The following Review discusses examples of PAT tools implemented in flow chemistry for the preparation of small organic molecules, and applications of self-optimization tools.
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