Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 24, Pages 13513-13520Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202104024
Keywords
antibacterial agents; carbon monoxide; MRSA; photooxidation; wound healing
Categories
Funding
- National Key R&D Program of China [2020YFA0710700]
- National Natural Scientific Foundation of China (NNSFC) Projects [51690150, 51690154, 52073270, 51722307, 51973206]
- Fundamental Research Funds for the Central Universities [WK2060190102]
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Researchers have developed nonmetallic CO-releasing micelles that selectively target S. aureus, releasing CO under red light irradiation. These micelles show a selective bactericidal effect and can cure MRSA-infected wounds by eradicating the pathogens and accelerating wound healing.
Carbon monoxide (CO) is an important gaseous signaling molecule. The use of CO-releasing molecules such as metal carbonyls enables the elucidation of the pleiotropic functions of CO. Although metal carbonyls show a broad-spectrum antimicrobial activity, it remains unclear whether the bactericidal property originates from the transition metals or the released CO. Here, we develop nonmetallic CO-releasing micelles via a photooxygenation mechanism of 3-hydroxyflavone derivatives, enabling CO release under red light irradiation (e.g., 650 nm). Unlike metal carbonyls that non-specifically internalize into both Gram-positive and Gram-negative bacteria, the nonmetallic micelles are selectively taken up by S. aureus instead of E. coli cells, exerting a selective bactericidal effect. Further, we demonstrate that the CO-releasing micelles can cure methicillin-resistant S. aureus (MRSA)-infected wounds, simultaneously eradicating MRSA pathogens and accelerating wound healing.
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