A report of pregnancy following ICSI in one of two sisters with familiar primary ciliary dyskinesia

Primary ciliary dyskinesia (PCD) is a disorder of structure and function of motor ciliary and dyskinetic activity of ciliary in the fallopian tubes of affected women and could lead to infertility in some cases. In vitro fertilisation (IVF) is a choice of treatment in infertile women with PCD, which could conquer the tubal dysfunction. In this case study, we report a PCD affected woman with infertility who was treated by IVF and pregnancy was achieved but it failed due to the spontaneous abortion. We also performed whole-exome sequencing for this case and her PCD-affected sister, which did not reveal any genetic abnormality related to the PCD or infertility.

Automated summary

Primary ciliary dyskinesia (PCD) is a disorder that affects motor ciliary structure and function in the fallopian tubes of women, potentially leading to infertility. In vitro fertilisation (IVF) is a treatment option for infertile women with PCD, but successful pregnancies achieved through IVF may still result in spontaneous abortions. Genetic sequencing did not reveal any abnormalities related to PCD or infertility in the case study mentioned.