4.8 Article

Efficient Chiral Nanosenor Based on Tip-Modified Nanochannels

Journal

ANALYTICAL CHEMISTRY
Volume 93, Issue 15, Pages 6145-6150

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c05390

Keywords

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Funding

  1. National Natural Science Foundation of China [2207010149, 21772055]
  2. 111 Project [B17019]
  3. Self-Determined Research Funds of CCNU from the colleges' basic research and operation of MOE

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The study developed a chiral nanosensor based on a nanochannel system, allowing for efficient selective recognition of chiral drug enantiomers. By utilizing L-alanine-pillar[5]arenes as selective receptors, the system demonstrated high efficiency in chiral recognition.
Enantiomers of various drug molecules have a specific effect on living organisms. Accordingly, developing a sample method for the efficient and rapid recognition of chiral drug enantiomers is of great industrial value and physiological significance. Here, inspired by the structure of ion channels in living organisms, we developed a chiral nanosensor based on an artificial tip-modified nanochannel system that allows efficient selective recognition of chiral drugs. In this system, L-alanine-pillar[5]arenes as selective receptors were introduced on the tip side of conical nanochannels to form an enantioselective gate. The selective coefficient of our system toward R-propranolol is 4.96, which is higher than the traditional fully modified nanochannels in this work.

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