COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study

Article Immunology

Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study

Olivia S. Kates et al.

Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Surgery

COVID-19 in transplant recipients: The Spanish experience

Elisabeth Coll et al.

Summary: This study reported the experience of solid organ and hematopoietic stem cell transplant recipients diagnosed with COVID-19 in Spain until July 13, 2020. The incidence of COVID-19 in transplant recipients was higher than the general population. Most patients required hospitalization, and adjusting immunosuppression could improve survival rates. Risk factors for death included age, lung transplantation, and hospital-acquired COVID-19.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Immunology

COVID-19 in solid organ transplant recipients: No difference in survival compared to general population

Matteo Rinaldi et al.

Summary: This study compared SOT recipients and non-SOT patients with COVID-19 and found that the 30-day mortality rate among SOT recipients was similar to non-SOT patients, but with higher rates of respiratory failure and superinfections.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Article Immunology

COVID-19 in Solid Organ Transplantation: A Matched Retrospective Cohort Study and Evaluation of Immunosuppression Management

Marta Miarons et al.

Summary: This study investigated the epidemiological and clinical characteristics of solid organ transplant patients during the SARS-CoV-2 epidemic in Barcelona, Spain. The results showed a trend towards higher mortality in SOT recipients compared to controls, with a notable risk of drug-drug interactions.

TRANSPLANTATION (2021)

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Article Surgery

An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients

Vinay Nair et al.

Summary: This study compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients with a transplant naive population. The study found that SOT patients had a higher combined risk of death or mechanical ventilation compared to a control group matched for age, gender, and comorbidities. Factors such as age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m(2) were significant predictors of combined death or mechanical ventilation.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery

Outcomes of COVID-19 in hospitalized solid organ transplant recipients compared to a matched cohort of non-transplant patients at a national healthcare system in the United States

Arielle M. Fisher et al.

Summary: This study compared the clinical outcomes of SOT recipients with COVID-19 to non-SOT recipients during hospitalization, finding that SOT recipients had higher mortality rates and were more likely to require mechanical ventilation, develop acute kidney injury, and receive vasopressor support during hospitalization.

CLINICAL TRANSPLANTATION (2021)

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Editorial Material Virology

mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses

Basil S. Karam et al.

Summary: The mTOR pathway plays a crucial role in viral infections, with inhibiting mTOR potentially leading to suppression of virus growth and replication. Recent studies suggest the modulation of mTOR in SARS-CoV-2 infection, highlighting the potential of mTOR inhibitors as an effective treatment for coronavirus diseases.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Letter Medicine, General & Internal

Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers

Ninh T. Nguyen et al.

JAMA NETWORK OPEN (2021)

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Article Immunology

COVID-19 in Lung Transplant Recipients

Jonathan Messika et al.

Summary: The COVID-19 infection in the French cohort of lung transplant patients was severe, with most cases requiring hospitalization and a survival rate of 85.7%. Among the critically ill patients, invasive mechanical ventilation was required for over half, and thrombotic events occurred in 4 patients. Overweight was significantly associated with the risk of death.

TRANSPLANTATION (2021)

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Article Surgery