Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 86, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/aji.13433
Keywords
CD56(bright)CD56(dim); recurrent spontaneous abortion; uterine NK cells
Categories
Funding
- National Natural Science Foundation of China [81501275]
- Shandong Province College Science and Technology Plan Project [J18KA252]
- National Natural Science Foundation of Shangdong Province [ZR2019BH037]
- Weifang Science and Technology Development Project [2018YX056]
- Projects of Medical and Health Technology Development Program in Shandong province [2018WS051]
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RSA, defined as two or more consecutive pregnancy losses, poses a significant challenge for women of childbearing age, with evidence suggesting an immune background to the condition. Uterine natural killer (uNK) cells, as part of the innate immune system, play a crucial role in pregnancy by accounting for around 70% of total lymphocytes. Understanding the phenotype, origin, receptor, and function of uNK cells can shed light on their relationship with RSA.
Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large number of evidence confirm that there may be an immune background of RSA. As a member of the innate immune system, uterine natural killer (uNK) cells account for about 70% of total lymphocytes during pregnancy and play a critical role in the establishment and maintenance of pregnancy. This review mainly introduces the phenotype, origin, receptor, and function of uNK cells to illuminate its relationship with RSA.
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