4.6 Article

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation

Related references

Note: Only part of the references are listed.
Review Psychiatry

Are we repeating mistakes of the past? A review of the evidence for esketamine

Mark A. Horowitz et al.

Summary: Esketamine has been licensed for treating treatment-resistant depression in the USA, UK and Europe but the licensing trials did not establish its efficacy clearly. Safety signals like deaths, including suicides, and bladder damage were downplayed.

BRITISH JOURNAL OF PSYCHIATRY (2021)

Article Clinical Neurology

Esketamine Nasal Spray for Rapid Reduction of Depressive Symptoms in Patients With Major Depressive Disorder Who Have Active Suicide Ideation With Intent: Results of a Phase 3, Double-Blind, Randomized Study (ASPIRE II)

Dawn F. Ionescu et al.

Summary: This study confirmed rapid and robust reduction of depressive symptoms with esketamine nasal spray in severely ill patients with MDD who have active suicidal ideation with intent, showing significant improvements at 24 hours and earlier time points. Patients in both treatment groups experienced rapid reduction in suicidality scores, with no statistically significant difference between the groups. Common adverse events included dizziness, dissociation, nausea, dysgeusia, somnolence, headache, and paresthesia among esketamine-treated patients.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

Review Clinical Neurology

Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis

Anees Bahji et al.

Summary: The study showed that intravenous racemic ketamine was more effective and better tolerated than intranasal esketamine for the treatment of unipolar and bipolar major depression.

JOURNAL OF AFFECTIVE DISORDERS (2021)

Review Behavioral Sciences

The Effects of Ketamine on Cognition in Treatment-Resistant Depression: A Systematic Review and Priority Avenues for Future Research

Hartej Gill et al.

Summary: Research suggests that intravenous ketamine may have positive effects on cognition in TRD patients, including improvements in working memory and visual learning memory, although symptoms in anxious TRD participants may show more significant improvement.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Review Psychiatry

The acute antisuicidal effects of single-dose intravenous ketamine and intranasal esketamine in individuals with major depression and bipolar disorders: A systematic review and meta-analysis

Jiaqi Xiong et al.

Summary: The study aimed to evaluate the acute anti-suicidal ideation effects of single-dose ketamine in different formulations and routes of administration by pooling the results from randomized controlled trials. The findings suggest that intravenous ketamine and intranasal esketamine are associated with robust reductions in suicidal thoughts at 2-h, 4-h, and 24-h post-intervention. Further research on intramuscular, oral, and sublingual ketamine, as well as comparative studies, are needed to evaluate the efficacy of these formulations and routes of administration in reducing suicidal ideation.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

Editorial Material Psychiatry

Disruptive treatments in psychiatry

Eduard Vieta

REVISTA DE PSIQUIATRIA Y SALUD MENTAL (2020)

Article Neurosciences

Ketamine normalizes subgenual cingulate cortex hyper-activity in depression

Laurel S. Morris et al.

NEUROPSYCHOPHARMACOLOGY (2020)

Article Neurosciences

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

Chadi G. Abdallah et al.

NEUROPSYCHOPHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents

Matthew E. Klein et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Clinical Neurology

The identification, assessment and management of difficult-to-treat depression: An international consensus statement

R. H. McAllister-Williams et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

Review Pharmacology & Pharmacy

Integrating psychotherapy and psychopharmacology: psychedelic-assisted psychotherapy and other combined treatments

Kyle T. Greenway et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2020)

Letter Pharmacology & Pharmacy

Opioid Receptor mu-1 and Ketamine Effects in a Suicidal Depression Trial A Post Hoc Exploration

Michael F. Grunebaum et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2020)

Review Neurosciences

Rapid acting antidepressants in the mTOR pathway: Current evidence

K. Athira et al.

BRAIN RESEARCH BULLETIN (2020)

Article Neurosciences

Urothelial toxicity of esketamine in the treatment of depression

Hannelore Findeis et al.

PSYCHOPHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Genome-wide association study and polygenic risk score analysis of esketamine treatment response

Qingqin S. Li et al.

SCIENTIFIC REPORTS (2020)

Article Medicine, General & Internal

Bipolar disorders

Roger S McIntyre et al.

LANCET (2020)

Article Psychology, Clinical

Maintaining Rapid Antidepressant Effects Following Ketamine Infusion: A Major Unmet Need

George Papakostas

JOURNAL OF CLINICAL PSYCHIATRY (2020)

Article Psychology, Clinical

Efficacy of Esketamine Augmentation in Major Depressive Disorder: A Meta-Analysis

George Papakostas et al.

JOURNAL OF CLINICAL PSYCHIATRY (2020)

Review Clinical Neurology

The effect of intravenous, intranasal, and oral ketamine in mood disorders: A meta-analysis

Roger S. McIntyre et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

Article Pharmacology & Pharmacy

Body Mass Index as a Moderator of Treatment Response to Ketamine for Major Depressive Disorder

Marlene P. Freeman et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2020)

Review Clinical Neurology

A systematic meta-review of predictors of antidepressant treatment outcome in major depressive disorder

Kelly Perlman et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

Review Psychology, Clinical

Effectiveness of psychotherapy for treatment-resistant depression: a meta-analysis and meta-regression

Suzanne van Bronswijk et al.

PSYCHOLOGICAL MEDICINE (2019)

Article Medicine, Research & Experimental

ELEctroconvulsive therapy (ECT) vs. Ketamine in patients with Treatment-resistant Depression: The ELEKT-D study protocol

Sanjay J. Mathew et al.

CONTEMPORARY CLINICAL TRIALS (2019)

Article Multidisciplinary Sciences

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

Eric W. Lumsden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Editorial Material Psychiatry

A Word to the Wise About Intranasal Esketamine

Alan F. Schatzberg

AMERICAN JOURNAL OF PSYCHIATRY (2019)

Review Clinical Neurology

Esketamine for treatment resistant depression

Jennifer Swainson et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2019)

Letter Psychiatry

More Thoughts on Intranasal Esketamine: Response to Drevets et al.

Alan F. Schatzberg

AMERICAN JOURNAL OF PSYCHIATRY (2019)

Article Pediatrics

Successful Use of Ketamine for the Treatment of Psychotic Depression in a Teenager

Paria Zarrinnegar et al.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism

Nolan R. Williams et al.

MOLECULAR PSYCHIATRY (2019)

Review Psychology, Clinical

Oral Ketamine for Depression: A Systematic Review

Joshua D. Rosenblat et al.

JOURNAL OF CLINICAL PSYCHIATRY (2019)

Article Medicine, Research & Experimental

Comparative Effect of Intravenous Ketamine and Electroconvulsive Therapy in Major Depression: A Randomized Controlled Trial

Gholamreza Kheirabadi et al.

ADVANCED BIOMEDICAL RESEARCH (2019)

Editorial Material Psychiatry

Can a Framework Be Established for the Safe Use of Ketamine?

Robert Freedman et al.

AMERICAN JOURNAL OF PSYCHIATRY (2018)

Article Clinical Neurology

Rapid antidepressant effect of S-ketamine in schizophrenia

Lucie Bartova et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2018)

Review Clinical Neurology

Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials

Joshua D. Rosenblat et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

Article Clinical Neurology

Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions

Patricio Riva-Posse et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

Review Biochemistry & Molecular Biology

Mechanisms of ketamine action as an antidepressant

P. Zanos et al.

MOLECULAR PSYCHIATRY (2018)

Review Pharmacology & Pharmacy

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

Panos Zanos et al.

PHARMACOLOGICAL REVIEWS (2018)

Article Environmental Sciences

Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder

Carola Rong et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Psychiatry

Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism

Nolan R. Williams et al.

AMERICAN JOURNAL OF PSYCHIATRY (2018)

Review Psychiatry

Improving Depression Outcome by Patient-Centered Medical Management

A. John Rush et al.

AMERICAN JOURNAL OF PSYCHIATRY (2018)

Review Psychiatry

Side-effects associated with ketamine use in depression: a systematic review

Brooke Short et al.

LANCET PSYCHIATRY (2018)

Article Clinical Neurology

S-ketamine compared to etomidate during electroconvulsive therapy in major depression

Maxim Zavorotnyy et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2017)

Article Clinical Neurology

Anhedonia as a clinical correlate of suicidal thoughts in clinical ketamine trials

Elizabeth D. Ballard et al.

JOURNAL OF AFFECTIVE DISORDERS (2017)

Letter Psychology, Clinical

The Antidepressant Effect of Repeat Dose Intravenous Ketamine Is Delayed by Concurrent Benzodiazepine Use

C. Sophia Albott et al.

JOURNAL OF CLINICAL PSYCHIATRY (2017)

Article Psychology, Clinical

Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions

Chittaranjan Andrade

JOURNAL OF CLINICAL PSYCHIATRY (2017)

Article Psychiatry

A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders

Gerard Sanacora et al.

JAMA PSYCHIATRY (2017)

Letter Neurosciences

Ketamine and Psychosis History: Antidepressant Efficacy and Psychotomimetic Effects Postinfusion

Steven J. Pennybaker et al.

BIOLOGICAL PSYCHIATRY (2017)

Letter Psychiatry

A Survey of the Clinical, Off-Label Use of Ketamine as a Treatment for Psychiatric Disorders

Samuel T. Wilkinson et al.

AMERICAN JOURNAL OF PSYCHIATRY (2017)

Letter Neurosciences

The Use of Ketamine for the Treatment of Depression in the Context of Psychotic Symptoms

Carolina Medeiros da Frota Ribeiro et al.

BIOLOGICAL PSYCHIATRY (2016)

Review Pharmacology & Pharmacy

Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy

Marko A. Peltoniemi et al.

CLINICAL PHARMACOKINETICS (2016)

Article Pharmacology & Pharmacy

A New Perspective on the Anti-Suicide Effects With Ketamine Treatment A Procognitive Effect

Yena Lee et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2016)

Article Multidisciplinary Sciences

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Panos Zanos et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Ronald S. Duman et al.

NATURE MEDICINE (2016)

Letter Psychiatry

Benzodiazepines may reduce the effectiveness of ketamine in the treatment of depression

Nick Ford et al.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2015)

Review Urology & Nephrology

Possible pathophysiology of ketamine-related cystitis and associated treatment strategies

Jia-Fong Jhang et al.

INTERNATIONAL JOURNAL OF UROLOGY (2015)

Article Pharmacology & Pharmacy

Concomitant Benzodiazepine Use Attenuates Ketamine Response

Mark A. Frye et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2015)

Article Psychiatry

The use of ketamine in electroconvulsive therapy

Wojciech Merk et al.

PSYCHIATRIA POLSKA (2015)

Editorial Material Psychiatry

A Word to the Wise About Ketamine

Alan F. Schatzberg

AMERICAN JOURNAL OF PSYCHIATRY (2014)

Article Neurosciences

A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder

Kyle A. B. Lapidus et al.

BIOLOGICAL PSYCHIATRY (2014)

Article Clinical Neurology

Do the dissociative side effects of ketamine mediate its antidepressant effects?

David A. Luckenbaugh et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

Article Psychology, Clinical

Clinical Predictors of Ketamine Response in Treatment-Resistant Major Depression

Mark J. Niciu et al.

JOURNAL OF CLINICAL PSYCHIATRY (2014)

Article Neurosciences

Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

Carolyn I. Rodriguez et al.

NEUROPSYCHOPHARMACOLOGY (2013)

Article Urology & Nephrology

The prevalence and natural history of urinary symptoms among recreational ketamine users

Adam R. Winstock et al.

BJU INTERNATIONAL (2012)

Article Neurosciences

The Mu-Opioid Receptor and the NMDA Receptor Associate in PAG Neurons: Implications in Pain Control

Maria Rodriguez-Munoz et al.

NEUROPSYCHOPHARMACOLOGY (2012)

Review Multidisciplinary Sciences

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Ronald S. Duman et al.

SCIENCE (2012)

Review Clinical Neurology

Rapid decrease in depressive symptoms with an N-methyl-D-aspartate antagonist in ECT-resistant major depression

Lobna Ibrahim et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

Article Psychiatry

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Nancy Diazgranados et al.

ARCHIVES OF GENERAL PSYCHIATRY (2010)

Review Pharmacology & Pharmacy

Is the significant superiority of escitalopram compared with other antidepressants clinically relevant?

Stuart A. Montgomery et al.

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY (2009)

Article Psychology, Clinical

Attentional bias to incentive stimuli in frequent ketamine users

C. J. A. Morgan et al.

PSYCHOLOGICAL MEDICINE (2008)

Article Urology & Nephrology

Ketamine-associated ulcerative cystitis: A new clinical entity

Rohan Shahani et al.

UROLOGY (2007)

Review Neurosciences

Acute and chronic effects of ketamine upon human memory: a review

Celia J. A. Morgan et al.

PSYCHOPHARMACOLOGY (2006)