Journal
ALZHEIMERS & DEMENTIA
Volume 17, Issue 7, Pages 1134-1144Publisher
WILEY
DOI: 10.1002/alz.12288
Keywords
Alzheimer' s disease; blood pressure; blood pressure complexity; blood pressure variability; dementia; prospective cohort
Categories
Funding
- Erasmus Medical Center, Rotterdam
- Erasmus University, Rotterdam
- Netherlands Organization for the Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- Janssen Prevention Center
- ZonMw Memorabel [73305095005]
- Alzheimer Nederland through the Netherlands Consortium of Dementia Cohorts (NCDC)
- Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation [CVON 2018-28]
- Dutch Federation of University Medical Centres
- Netherlands Organisation for Health Research and Development
- Royal Netherlands Academy of Sciences
- American Heart Association [20POST35120057]
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The study suggests that lower complexity and higher variability of beat-to-beat SBP are potential novel risk factors or biomarkers for dementia.
Introduction We hypothesized that subclinical disruption in blood pressure (BP) dynamics, captured by lower complexity and higher variability, may contribute to dementia risk, above and beyond BP levels. Methods This prospective cohort study followed 1835 older adults from 1997 to 2016, with BP complexity quantified by sample entropy and BP variability quantified by coefficient of variation using beat-to-beat BP measured at baseline. Results Three hundred thirty-four participants developed dementia over 20 years. Reduced systolic BP (SBP) complexity was associated with a higher risk of dementia (hazard ratio [HR] comparing extreme quintiles: 1.55; 95% confidence interval [CI]: 1.09-2.20). Higher SBP variability was also associated with a higher risk of dementia (HR comparing extreme quintiles: 1.57; 95% CI: 1.11-2.22. These findings were observed after adjusting for age, sex, apolipoprotein E (APOE) genotype, mean SBP, and other confounding factors. Discussions Our findings suggest that lower complexity and higher variability of beat-to-beat SBP are potential novel risk factors or biomarkers for dementia.
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