4.6 Review

The ingenious mast cell: Contemporary insights into mast cell behavior and function

Related references

Note: Only part of the references are listed.
Article Hematology

Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis

Georg Greiner et al.

Summary: The study showed that in patients with mastocytosis, those with HαT had higher levels of tryptase and were more likely to experience hymenoptera venom hypersensitivity reactions and severe cardiovascular mediator-related symptoms/anaphylaxis. This suggests that HαT could be a novel emerging robust biomarker in mastocytosis.

BLOOD (2021)

Article Allergy

Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8

Anabel Gonzalez-Gil et al.

Summary: The study identified a high molecular weight Siglec-8 ligand on the mucus layer of human airways, composed of DMBT1S8 with picomolar affinity for Siglec-8. This finding is important for understanding the pathogenesis and treatment of airway diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Allergy

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1

Jonathan J. Lyons et al.

Summary: This study revealed that genotypes have a significant impact on the severity of anaphylaxis in humans, particularly in association with H alpha T. The prevalence of H alpha T was higher in healthy individuals and controls with nonatopic disease, and it was particularly prominent in systemic mastocytosis and idiopathic anaphylaxis, suggesting it as a potential risk factor for severe allergic reactions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Allergy

MRGPRX2 and Immediate Drug Hypersensitivity: Insights From Cultured Human Mast Cells

J. Elst et al.

Summary: Silencing MRGPRX2 in human MCs can provide important insights into its role in IDH. Induction of calcium signals does not necessarily translate into a secretory response, so measuring degranulation reaction seems more meaningful in the context of drug testing.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2021)

Article Allergy

Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development

Fiona K. Hamey et al.

Summary: The study explored the differentiation pathways of basophils and mast cells at the single-cell level in mice using multicolor flow cytometry, high-coverage single-cell RNA sequencing, and cell fate assays. The results provided a detailed map of differentiation and revealed gene expression changes during the process. Flow cytometry and transcriptional profiling successfully predicted the bipotent phenotype of a previously uncharacterized population of peritoneal basophil-mast cell progenitors.

ALLERGY (2021)

Review Allergy

Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Helen Kuehn et al.

Summary: MRGPRX2 is a multiligand receptor highly expressed on skin mast cells, whose agonists may serve as potential biomarkers for the progression of cutaneous inflammatory diseases and response to treatment in patients with inflammatory and pruritic skin diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Allergy

miR103a-3p in extracellular vesicles from FcεRI- aggregated human mast cells enhances IL-5 production by group 2 innate lymphoid cells

Shota Toyoshima et al.

Summary: The study revealed that EVs derived from MCs can activate ILC2s through miR103a-3p, leading to increased production of IL-5 and exacerbating eosinophilic allergic inflammation.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Immunology

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Daniel F. Dwyer et al.

Summary: A comprehensive analysis of human MC hyperplasia in CRSwNP, a T2 cytokine-mediated inflammatory disease, was conducted using flow cytometry and single-cell RNA-sequencing. The study revealed distinct inflammation-associated effector programs of MCs, indicating that in situ MC proliferation is a major component of MC hyperplasia in human T2 inflammation.

SCIENCE IMMUNOLOGY (2021)

Review Allergy

New treatments for chronic urticaria

Pavel Kolkhir et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2020)

Article Allergy

Mast cells initiate the vascular response to contact allergens by sensing cell stress

Anja Hoppe et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Cell Biology

A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions

Andrea Mencarelli et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

Article Multidisciplinary Sciences

Lineage tracing on transcriptional landscapes links state to fate during differentiation

Caleb Weinreb et al.

SCIENCE (2020)

Review Immunology

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns

Stephen J. Galli et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Article Immunology

Localization-Specific Expression of CCR1 and CCR5 by Mast Cell Progenitors

Maya Salomonsson et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Dermatology

Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin

Anke Weitzmann et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

Article Immunology

Skin Mast Cells Contribute to Sporothrix schenckii Infection

Qingqing Jiao et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Deciphering human macrophage development at single-cell resolution

Zhilei Bian et al.

NATURE (2020)

Article Cell & Tissue Engineering

A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types

Nouraiz Ahmed et al.

STEM CELL REPORTS (2020)

Review Biochemistry & Molecular Biology

FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes

Mario Lecce et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Allergy

Hereditary Alpha-Tryptasemia: UK Prevalence and Variability in Disease Expression

Rebecca C. Robey et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Article Medicine, Research & Experimental

Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis

Melanie C. Dispenza et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Immunology

Protective and pathogenic roles for mast cells during viral infections

Abhay P. S. Rathore et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

Review Allergy

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

Marcus Maurer et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2020)

Review Dermatology

The complex role of mast cells in fungal infections

Qingqing Jiao et al.

EXPERIMENTAL DERMATOLOGY (2019)

Article Neurosciences

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

Dustin P. Green et al.

NEURON (2019)

Article Allergy

Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

Peter Valent et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Review Respiratory System

The emerging role of mast cell proteases in asthma

Gunnar Pejler

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Biochemistry & Molecular Biology

Mast Cells in Viral, Bacterial, and Fungal Infection Immunity

Adrian M. Piliponsky et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Immunology

Identification of two distinct pathways of human myelopoiesis

Roy Drissen et al.

SCIENCE IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Mast Cell Responses to Viruses and Pathogen Products

Jean S. Marshall et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Future Needs in Mast Cell Biology

Gilda Varricchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Mast cells are critical for controlling the bacterial burden and the healing of infected wounds

C. Zimmermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

Henry R. Maun et al.

Article Multidisciplinary Sciences

Decoding human fetal liver haematopoiesis

Dorin-Mirel Popescu et al.

NATURE (2019)

Article Medicine, General & Internal

Ligelizumab for Chronic Spontaneous Urticaria

Marcus Maurer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Allergy

Mast cell disorders: From infancy to maturity

Amy Wilcock et al.

ALLERGY (2019)

Article Immunology

Chymase-Cre; Mcl-1fl/fl Mice Exhibit Reduced Numbers of Mucosal Mast Cells

Ying Luo et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Allergy

Mast cells as protectors of health

Anne Dudeck et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Immunology

Mast cells as sources of cytokines, chemokines, and growth factors

Kaori Mukai et al.

IMMUNOLOGICAL REVIEWS (2018)

Article Allergy

Thirdhand smoke component can exacerbate a mouse asthma model through mast cells

Mang Yu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Allergy

Mast cells signal their importance in health and disease

Ana Olivera et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Immunology

Mast Cells as Drivers of Disease and Therapeutic Targets

Frank Siebenhaar et al.

TRENDS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Activation of Eosinophils and Mast Cells in Functional Dyspepsia: an Ultrastructural Evaluation

Hanne Vanheel et al.

SCIENTIFIC REPORTS (2018)

Review Immunology

Immunoglobulin E-Mediated Autoimmunity

Marcus Maurer et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Population snapshots predict early haematopoietic and erythroid hierarchies

Betsabeh Khoramian Tusi et al.

NATURE (2018)

Article Multidisciplinary Sciences

Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation

Do-Kyun Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Multidisciplinary Sciences

From haematopoietic stem cells to complex differentiation landscapes

Elisa Laurenti et al.

NATURE (2018)

Article Allergy

A humanized mouse model of anaphylactic peanut allergy

Oliver T. Burton et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Endocrinology & Metabolism

Mast Cells Are Critical Regulators of Bone Fracture-Induced Inflammation and Osteoclast Formation and Activity

Jochen Kroner et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

Review Cell Biology

Mast cell secretome: Soluble and vesicular components

Krisztina V. Vukman et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

Review Immunology

Positive and Negative Signals in Mast Cell Activation

Silvia Bulfone-Paus et al.

TRENDS IN IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis

Ofir Klein et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Defective bone repair in mast cell-deficient cpa3Cre/+mice

Jose Luis Ramirez-GarciaLuna et al.

PLOS ONE (2017)

Review Allergy

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

Robert P. Schleimer et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Pharmacology & Pharmacy

Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function

Joseph M. Kulinski et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

IL-33 and Thymic Stromal Lymphopoietin in mast cell functions

Rohit Saluja et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Article Allergy

Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

Paul J. Bryce et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Medicine, Research & Experimental

Different activation signals induce distinct mast cell degranulation strategies

Nicolas Gaudenzio et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, General & Internal

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

Steven E. Boyden et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medical Laboratory Technology

Mast cells and their activation in lung disease

Harvinder Virk et al.

TRANSLATIONAL RESEARCH (2016)

Article Oncology

Mast cells promote melanoma colonization of lungs

Helena Ohrviki et al.

ONCOTARGET (2016)

Article Multidisciplinary Sciences

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Benjamin D. McNeil et al.

NATURE (2015)

Article Allergy

Molecular targets on mast cells and basophils for novel therapies

Ilkka T. Harvima et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

Article Medicine, Research & Experimental

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis

Albert Dahdah et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Immunology

Vesicular trafficking and signaling for cytokine and clemokine secretion in mast cells

Ulrich Blank et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Immunology

Mast cell mediators: their differential release and the secretory pathways involved

Tae Chul Moon et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Immunology

Mast cell secretory granules: armed for battle

Sara Wernersson et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Allergy

Human mast cells arise from a common circulating progenitor

Katariina Maaninka et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Medicine, General & Internal

Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria

Marcus Maurer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Allergy

Interleukin-33 in allergy

Tatsukuni Ohno et al.

ALLERGY (2012)

Review Immunology

Widespread Immunological Functions of Mast Cells: Fact or Fiction?

Hans-Reimer Rodewald et al.

IMMUNITY (2012)

Review Immunology

New models for analyzing mast cell functions in vivo

Laurent L. Reber et al.

TRENDS IN IMMUNOLOGY (2012)

Review Immunology

Mast cell chemotaxis - chemoattractants and signaling pathways

Ivana Halova et al.

FRONTIERS IN IMMUNOLOGY (2012)

Review Immunology

Mast cells respond to cell injury through the recognition of IL-33

Carolina Lunderius-Andersson et al.

FRONTIERS IN IMMUNOLOGY (2012)

Article Immunology

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

Mattias Enoksson et al.

JOURNAL OF IMMUNOLOGY (2011)

Article Cell & Tissue Engineering

Distinguishing Mast Cell and Granulocyte Differentiation at the Single-Cell Level

Christopher B. Franco et al.

CELL STEM CELL (2010)

Article Allergy

Mast cell activation syndrome: Proposed diagnostic criteria

Cem Akin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Review Immunology

Differential release of mast cell mediators and the pathogenesis of inflammation

Theoharis C. Theoharides et al.

IMMUNOLOGICAL REVIEWS (2007)

Article Medicine, Research & Experimental

Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion

Marie Fischer et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Multidisciplinary Sciences

Mast cells can enhance resistance to snake and honeybee venoms

Martin Metz et al.

SCIENCE (2006)

Review Cell Biology

Compound exocytosis: Mechanisms and functional significance

JA Pickett et al.

TRAFFIC (2006)

Article Multidisciplinary Sciences

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

Y Arinobu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Identification of mast cell progenitors in adult mice

CC Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Phosphorylation of SNAP-23 regulates exocytosis from mast cells

G Hepp et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Cell Biology

Ultrastructural studies of human basophils and mast cells

AM Dvorak

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity

M Maurer et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Impact of engagement of FcδRI and CC chemokine receptor 1 on mast cell activation and motility

M Toda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Multidisciplinary Sciences

Points of control in inflammation

C Nathan

NATURE (2002)

Article Biochemistry & Molecular Biology

Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4

M Juremalm et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)