Journal
ALLERGY
Volume 77, Issue 1, Pages 83-99Publisher
WILEY
DOI: 10.1111/all.14881
Keywords
allergy; anaphylaxis; animal models; asthma; inflammation; Mast cells; mastocytosis; urticaria
Categories
Funding
- Cancerfonden
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- Vetenskapsradet
- Swedish Research Council
- Swedish Cancer Society
- Division of Intramural Research, NIAID, NIH
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Mast cells play a crucial role in maintaining homeostasis and surveillance of the human body, releasing various mediators that affect both immune and non-immune cells. Research using animal models has contributed to a better understanding of mast cell function in health and disease.
Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell-driven diseases and discuss the development of novel strategies to treat such conditions.
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