Journal
ALLERGY
Volume 76, Issue 12, Pages 3627-3641Publisher
WILEY
DOI: 10.1111/all.14908
Keywords
allergy treatment; basic mechanisms in allergy; biologics; biomarkers; IgE; immunotherapy; tolerance induction; vaccines and mechanisms
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IgE-mediated allergy is a common hypersensitivity disease impacting over 30% of the population. Allergen-specific IgE triggers release of inflammatory mediators, while inducing IgG and IgA antibodies can compete with IgE for allergen binding to prevent allergic responses. Anti-IgE treatment can also prevent IgE from binding to receptors on mast cells and basophils to inhibit allergic reactions.
Immunoglobulin E (IgE)-mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individuals. This is termed allergic sensitization, which occurs mainly in early childhood. Allergen-specific IgE then binds to the high (Fc epsilon RI) and low-affinity receptors (Fc epsilon RII, also called CD23) for IgE on effector cells and antigen-presenting cells. Subsequent and repeated allergen exposure increases allergen-specific IgE levels and, by receptor cross-linking, triggers immediate release of inflammatory mediators from mast cells and basophils whereas IgE-facilitated allergen presentation perpetuates T cell-mediated allergic inflammation. Due to engagement of receptors which are highly selective for IgE, even tiny amounts of allergens can induce massive inflammation. Naturally occurring allergen-specific IgG and IgA antibodies usually recognize different epitopes on allergens compared with IgE and do not efficiently interfere with allergen-induced inflammation. However, IgG and IgA antibodies to these important IgE epitopes can be induced by allergen-specific immunotherapy or by passive immunization. These will lead to competition with IgE for binding with the allergen and prevent allergic responses. Similarly, anti-IgE treatment does the same by preventing IgE from binding to its receptor on mast cells and basophils. Here, we review the complex interplay of allergen-specific IgE, IgG and IgA and the corresponding cell receptors in allergic diseases and its relevance for diagnosis, treatment and prevention of allergy.
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