Journal
ADVANCES IN COLLOID AND INTERFACE SCIENCE
Volume 290, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.cis.2021.102384
Keywords
Electrospraying; Encapsulation; Poorly water-soluble bioactives; Hydrophobic biomolecules; Controlled delivery
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Funding
- National Elites Foundation of Iran [6752766]
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Hydrophobicity and low aqueous-solubility are persistent challenges for the development and applications of drugs/nutraceuticals. Nanotechnology strategies and electrospraying technology are being utilized to address these challenges effectively.
Hydrophobicity and low aqueous-solubility of different drugs/nutraceuticals remain a persistent challenge for their development and clinical/food applications. A range of nanotechnology strategies have been implemented to address this issue, and amongst which a particular emphasis has been made on those that afford an improved biological performance and tunable release kinetic of bioactives through a one-step process. More recently, the technique of electrospraying (or electrohydrodynamic atomization) has attained notable impulse in virtue of its potential to tune attributes of nano/micro-structured particles (e.g., porosity, particle size, etc.), rendering a near zero-order release kinetics, diminished burst release manner, as well as its simplicity, reproducibility, and applicability to a broad spectrum of hydrophobic and poorly water-soluble bioactives. Controlled morphology or monodispersity of designed particles could be properly obtained via electrospraying, with a high encapsulation efficiency and without unfavorable denaturation of thermosensitive bioactives upon encapsulation. This paper overviews the recent technological advances in electrospraying for the encapsulation of low queues-soluble bioactive agents. State-of-the-art, advantages, applications, and challenges for its implementation in pharmaceutical/food researches are also discussed. (C) 2021 Elsevier B.V. All rights reserved.
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