Journal
ADVANCED POWDER TECHNOLOGY
Volume 32, Issue 5, Pages 1750-1756Publisher
ELSEVIER
DOI: 10.1016/j.apt.2021.03.032
Keywords
Amorphous solid dispersion; FTIR; Pyrrolidone skeleton; Spray drying; Supersaturation
Categories
Funding
- Hosokawa Powder Technology Foundation (Osaka, Japan)
- Information Center of Particle Technology (Tokyo, Japan)
- Nagai Memorial Research Scholarship from the Pharmaceutical Society of Japan (Tokyo, Japan)
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This study investigated methods to improve the water solubility of curcumin and maintain its supersaturated state. Experimental results indicate that the addition of alpha-cyclodextrin can help inhibit the nucleation and crystal growth of curcumin.
Although curcumin is considered to have various therapeutic effects, its use as a functional food or supplement is restricted owing to its low water solubility and bioavailability. To increase the solubility of curcumin in water, the use of polyvinylpyrrolidone (PVP) and vinylpyrrolidone-vinyl acetate copolymers with a pyrrolidone skeleton was noted to be promising. In particular, the bi-component formulations of curcumin/PVP prepared through spray drying exhibited an amorphous state in powder X-ray diffraction observations and temporally increased the apparent solubility of curcumin to over 5000 times that of untreated curcumin; nevertheless, after 24 h, the solubility decreased owing to the unstable supersaturated state of curcumin. The addition of alpha-cyclodextrin (alpha-CyD) in the bi-component curcumin/PVP formulation helped maintain the supersaturated state of curcumin, whereas the addition of b-and c-CyD led to the collapse of the supersaturated state. The addition of alpha-CyD can likely help inhibit the nucleation and crystal growth of curcumin, through the interaction among the solubilized units of curcumin/PVP and alpha-CyD. (C) 2021 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.
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