Journal
ADVANCED MATERIALS
Volume 33, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202008481
Keywords
anti‐ inflammation; hydrogen sulfide; hyperactive immunity; NIR‐ II fluorescence; photothermal therapy
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Funding
- Faculty of Health Sciences, University of Macau
- Start-up Research Grant (SRG) of University of Macau [SRG2018-00130-FHS]
- Science and Technology Development Fund, Macau SAR [0109/2018/A3, 0011/2019/AKP]
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The gas-modulated photothermal immunogenicity strategy, which integrates a polysulfide-based hydrogen sulfide donor with a conjugated polymer, shows great potential in inhibiting tumor growth and limiting inflammation.
Photothermal therapy (PTT), one of the most-potent cancer therapeutic strategies known, is highlighted with excessive inflammatory response, while ablating cancer with immunogenic death. This hyperactive immune response may override PTT-triggered immunogenicity, exacerbate skin empyrosis, and incur permanent tissue injury and high-profile tumor regeneration. Therefore, an anticancer balance between pathological and protective immune response is urgently needed for an advanced photothermal therapeutic tactic. Herein, a gas-modulated photothermal immunogenicity strategy is proposed by integrating an amphiphilic-conjugated polymer with a polysulfide-based hydrogen sulfide (H2S) donor (2,2 '-dipyridyl tetrasulfide@CP-PEG) (where CP = conjugated polymer and PEG = poly(ethylene glycol)). The CP is endowed with NIR-II fluorescence capacity and favorable photothermal effect, tracing the tumor for precise therapeutics. The polysulfide donor can release H2S triggered by intracellular glutathione, which elicits mitochondrial dysfunction and robust anti-inflammation effect. Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1 beta) cytokines. Moreover, the regulated inflammation accelerates PTT-induced wound healing. A H2S-modulated PTT with adaptive immune response is thus recommended as an advanced strategy to cancer therapeutics.
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