Journal
ADVANCED MATERIALS
Volume 33, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202006644
Keywords
brain extracellular space; brightness; fluorescence; organic nanoparticles; single‐ particle tracking; stealth
Categories
Funding
- European Union [841379, 793296]
- US-France-Belgium iREU Site in Translational Chemistry (NSF) [1560390]
- Conseil Regional d'Aquitaine (Chaire d'accueil)
- Agence Nationale de la Recherche [ANR-15-CE16-0004]
- IdEx Bordeaux [ANR-10-IDEX-03-02]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1560390] Funding Source: National Science Foundation
- Marie Curie Actions (MSCA) [841379, 793296] Funding Source: Marie Curie Actions (MSCA)
- Agence Nationale de la Recherche (ANR) [ANR-15-CE16-0004] Funding Source: Agence Nationale de la Recherche (ANR)
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Fluorescent nanoparticles for bioimaging applications need to maintain chemical and photostability, small size, biocompatibility, high brightness, and good solubility, while facing the critical challenge of interacting with cellular membranes. Stealthy FONs with bright, size-tunable, red-emitting properties are reported here, allowing for deep diffusion in brain tissue without the need for antifouling agents.
Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 mu m deep in brain tissue are imaged and tracked.
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