Beyond Photo: Xdynamic Therapies in Fighting Cancer

Reactive oxygen species (ROS)-related therapeutic approaches are developed as a promising modality for cancer treatment because the aberrant increase of intracellular ROS level can cause cell death due to nonspecific oxidation damage to key cellular biomolecules. However, the most widely considered strategy, photodynamic therapy (PDT), suffers from critical limitations such as limited tissue-penetration depth, high oxygen dependence, and phototoxicity. Non-photo-induced ROS generation strategies, which are defined as Xdynamic therapies (X = sono, radio, microwave, chemo, thermo, and electro), show good potential to overcome the drawbacks of PDT. Herein, recent advances in the development of Xdynamic therapies, including the design of systems, the working mechanisms, and examples of cancer therapy application, are introduced. Furthermore, the approaches to enhance treatment efficiency of Xdynamic therapy are highlighted. Finally, the perspectives and challenges of these strategies are also discussed.

Automated summary

This paper discusses the potential and recent advances of non-photo-induced ROS generation strategies (Xdynamic therapies) in cancer treatment, highlighting their ability to overcome the limitations of photodynamic therapy (PDT) and enhance treatment efficiency. The design, working mechanisms, and examples of application in cancer therapy of Xdynamic therapies are introduced, along with approaches to enhance treatment efficiency. Perspectives and challenges of these strategies are also discussed.