Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 175, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.05.008
Keywords
Tumor microenvironment; Metastatic niche; Tissue engineering; Organ-on-chip; Microfluidic model; Microphysiological system
Categories
Funding
- National Institutes of Health [R21 CA223836, UG3/UH3 HL141800, UG3DK122639, UG3/UH3 TR002137, R61HL15430701, U54 CA217378]
- University of California System's Cancer Research Coordinating Committee [C21CR2153]
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Tissue engineered microfluidic devices have emerged as a powerful tool to mimic human physiology and pathology with organ-specificity in vitro. Current research on tumor-on-chip models has led to discoveries about cancer immunobiology and response to therapy, with future focus on developing autologous or multi-organ systems including the immune system.
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems that accu-rately mimic human oncology - a requirement for the development of more effective therapies for these patients - remain elusive. Tumor development is an organ-specific process that involves modification of existing tissue features, recruitment of other cell types, and eventual metastasis to distant organs. Recently, tissue engineered microfluidic devices have emerged as a powerful in vitro tool to model human physiology and pathology with organ-specificity. These organ-on-chip platforms consist of cells cultured in 3D hydrogels and offer precise control over geometry, biological components, and physiochemical properties. Here, we review progress towards organ-specific microfluidic models of the primary and metastatic tumor microenvironments. Despite the field's infancy, these tumor-on-chip models have enabled discoveries about cancer immunobiology and response to therapy. Future work should focus on the development of autologous or multi-organ systems and inclusion of the immune system. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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