Journal
ACTA TROPICA
Volume 217, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2021.105872
Keywords
rDNA; Parasite; Heterochromatin; Histone acetylation; Histone methylation
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Funding
- National Council of Science and Technology, CONACyT [2018-000012-01NACF-07226]
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Giardia duodenalis is a parasite that causes numerous diarrheal diseases worldwide. Despite needing fewer components than other eukaryotes, Giardia still contains core histones and epigenetic marks, which suggest a control mechanism for gene expression.
Giardia duodenalis is a parasite that causes a large number of diarrheal diseases around the world. It is noteworthy that in a large number of processes, Giardia requires fewer components than other eukaryotes, even without some organelles such as mitochondria and peroxisomes. Despite this, core histones are known to exist in Giardia and epigenetic marks have been found on them, suggesting that they somehow control the expression of certain genes. The regulation of the expression of ribosomal DNA (rDNA) is essential, since it is required to maintain adequate levels of ribosomes and, given the nature of tandem repeat, it is a feasible area to create genomic instability. In Giardia, it is not known how this process occurs, but as in other eukaryotes, it is suggested through various epigenetic mechanisms. Thus, in the present work we seek to identify how chromatin is distributed through the Giardia rDNA and if there were histone marks that could control its expression.
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