Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation

Humans are exposed to varying amounts of ultraviolet radiation (UVR) through sunlight. UVR penetrates into human skin leading to release of neuropeptides, neurotransmitters and neuroendocrine hormones. These messengers released from local sensory nerves, keratinocytes, Langerhans cells (LCs), mast cells, melanocytes and endothelial cells (ECs) modulate local and systemic immune responses, mediate inflammation and promote differing cell biologic effects. In this review, we will focus on both animal and human studies that elucidate the roles of calcitonin gene-related peptide (CGRP), substance P (SP), nerve growth factor (NGF), nitric oxide and proopiomelanocortin (POMC) derivatives in mediating immune and inflammatory effects of exposure to UVR as well as other cell biologic effects of UVR exposure.

Automated summary

Exposure to ultraviolet radiation leads to the release of neuropeptides, neurotransmitters, and neuroendocrine hormones in human skin, modulating immune responses, mediating inflammation, and promoting various cell biological effects. This review focuses on the roles of specific molecules in mediating these effects in both animal and human studies.