Journal
ACS NANO
Volume 15, Issue 4, Pages 6517-6529Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c08790
Keywords
temperature-sensitive lipids; carbon nanotubes; photothermal therapy; gene therapy; synergistic therapies
Categories
Funding
- National Natural Science Foundation of China [21776044, 21606041, 21908019]
- National High Technology Research and Development Program (863 Program) of China [2014AA020707]
- Liaoning Provincial Natural Science Foundation [2019-ZD-0185]
- CAS international collaboration plan [E0632911ZX]
- National Key Research & Development Program of China [2018YFE0117800]
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The combination of peptide lipid (PL) and sucrose laurate (SL) coated carbon nanotubes has shown great potential for achieving controlled release of genes for anti-tumor activity through photothermal effects. The resulting SCNT-PS/siRNA delivery system exhibited high anti-tumor activity and efficient systemic delivery to tumor sites.
The combination of photothermal therapy (PTT) and gene therapy (GT) shows great potential to achieve synergistic anti-tumor activity. However, the lack of a controlled release of genes from carriers remains a severe hindrance. Herein, peptide lipid (PL) and sucrose laurate (SL) were used to coat single-walled carbon nanotubes (SCNTs) and multi-walled carbon nanotubes (MCNTs) to form bifunctional delivery systems (denoted SCNT-PS and MCNT-PS, respectively) with excellent temperature-sensitivity and photothermal performance. CNT/siRNA suppressed tumor growth by silencing survivin expression while exhibiting photothermal effects under near-infrared (NIR) light. SCNT-PS/siRNA showed very high anti-tumor activity, resulting in the complete inhibition of some tumors. It was highly efficient for systemic delivery to tumor sites and to facilitate siRNA release owing to the phase transition of the temperature-sensitive lipids, due to PL and SL coating. Thus, SCNT-PS/siRNA is a promising anti-tumor nanocarrier for combined PTT and GT.
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