Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 15, Pages 17243-17254Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c01125
Keywords
covalent-organic framework; single laser irradiation; NIR phototherapy; multi-modal imaging; theranostics
Funding
- NSFC [21971153, 21671122]
- Major Basic Research Projects of Shandong Natural Science Foundation [ZR2020ZD32]
- Taishan Scholars Climbing Program of Shandong Province
- China Postdoctoral Science Foundation [2020M682225]
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The study introduced a COF-based nanocomposite Fe3O4@COF-DhaTph as a multifunctional nanoagent for cancer theranostics under single 660 nm NIR irradiation. Apart from photothermal and photodynamic effects, this nanoagent also allows triple-modal magnetic resonance/photoacoustic/near-infrared thermal imaging, potentially advancing the application of COF-based multifunctional nanomaterials in cancer theranostics.
Imaging-guided phototherapy, including photothermal therapy and photodynamic therapy, has been emerging as a promising avenue for precision cancer treatment. However, the utilization of a single laser to induce combination phototherapy and multiple-model imaging remains a great challenge. Herein, we report, the first of its kind, a covalent-organic framework (COF)based magnetic core-shell nanocomposite, Fe3O4@COF-DhaTph, that is used as a multifunctional nanoagent for cancer theranostics under single 660 nm NIR irradiation. Besides significant photothermal and photodynamic effects, it still permits triple-modal magnetic resonance/ photoacoustic/near-infrared thermal (IR) imaging due to its unequaled magnetic and optical performance. We believe that the results obtained herein could obviously promote the application of COF-based multifunctional nanomaterials in cancer theranostics.
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