Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 16, Pages 18488-18499Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c00553
Keywords
osteosarcoma; scaffold; photothermal therapy; chemotherapy; synergistic effect
Funding
- National Key Research and Development Program of China [2019YFA0111300]
- National Natural Science Foundation of China [51903256, 21907113, 32001012, 81772368]
- Guangdong Province Science and Technology Innovation Special Fund (International Scientific Cooperation) [2018A050506035]
- Guangdong Natural Science Foundation [2017B090912007]
- China Postdoctoral Science Foundation [2019TQ0364]
- Guangdong Provincial Pearl River Talents Program [2019QN01Y131]
- Thousand Talents Plan
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A multifunctional local implantation platform was developed for synergistic photothermal therapy and chemotherapy treatment of osteosarcoma. The content of TiN and DOX in the scaffolds can be flexibly adjusted, providing both therapeutic effects and mechanical support for bone tissue. The scaffolds have the potential to be a universal platform for loading different therapeutic agents.
The postoperative tumor recurrence and chemotherapy resistance in clinical osteosarcoma treatment have raised an imperative need to develop local implants for selectively killing residual tumor cells and simultaneously provide a scaffold for effectively filling the tumor resection-induced bone defects. Herein, a multifunctional platform is developed through successively coating TiN microparticles and doxorubicin (DOX) on the surface of tricalcium phosphate (TCP) scaffolds to achieve synergetic effects of photothermal therapy and chemotherapy for osteosarcoma. The content of TiN and DOX in the scaffolds can be flexibly adjusted by immersing the scaffolds into the solution containing different concentrations of TiN and DOX. The excellent therapeutic effect was achieved both in vitro and in vivo through the precise photothermal therapy and localized controlled-release chemotherapy. Moreover, the overall bulk scaffolds provide the mechanical support for bone tissue when implanting scaffolds into bone defects resulting from surgical removal of osteosarcoma. Importantly, using the poly(D,L-lactide) (PDLLA) as the medium, the scaffolds can be exploited as a universal platform for loading different kinds of therapeutic agents. This study may provide insights into designing multifunctional local implantation for eradicating tumors after surgical interventions with mitigated side effects.
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