4.6 Article

An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity

Journal

LIFE-BASEL
Volume 11, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/life11030207

Keywords

antidepressant-like; anxiolytic; antioxidant; Carum carvi L; polyphenols; tail suspension test; light-dark chamber test; forced swim test; open field test; DPPH test; FRAP test

Funding

  1. Deanship of Scientific Research at Princess Nourah bint Abdulrahman University
  2. European project Horizon 2020 [MSCA-RISE-2016-734759-VAHVISTUS]

Ask authors/readers for more resources

The study investigates the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its antioxidant power, showing significant effects on both depression and anxiety after oral administration, and interesting antioxidant properties. The presence of 6 molecules belonging to polyphenols in the extract has been confirmed with HPLC analysis, encouraging further research to understand its action mechanism.
Depression and anxiety are widespread illnesses whose consequences on patients' social and professional lives are becoming ever more dangerous and severe. The study's objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its antioxidant power as they were recently associated. The predictive antidepressant activity was evaluated using the forced swimming and tail suspension test in mice, a preclinical behavioral model widely used to determine the efficacy of antidepressant drugs. As for anxiolytic-like activity, two models were used, namely the light/dark chamber test to measure the animal's degree of anxiety and the open field test to evaluate both anxiolytic and locomotor activity. The tests results indicate a remarkable antidepressant and anxiolytic-like effect after oral administration of the polyphenolic fraction of C. carvi and interesting antioxidant property. In the extract it has been confirmed the presence of 6 molecules belonging to polyphenols, identified with HPLC analysis. This study confirms and encourages the traditional use of the extract and appeals to further studies to understand its action mechanism.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available