Journal
LIFE-BASEL
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/life11020176
Keywords
trabecular meshwork; schlemm’ s canal; biomechanics; optical coherence tomography
Categories
Funding
- National Eye Institute [R01EY024158]
- W.H. Coulter Foundation Translational Research Partnership Program
Ask authors/readers for more resources
This study utilized high-resolution OCT to evaluate the impact of Schlemm's canal dilation on the biomechanical properties of the trabecular meshwork and the structure of collector channels. Results demonstrated pressure-dependent changes in the dimensions of Schlemm's canal and collector channels, with elastance curves shifting with increased pressure-dependent steady-state Schlemm's canal area. The study provides insights into the mechanisms of intraocular pressure control in glaucoma surgery.
Objective: To evaluate the change of biomechanical properties of the trabecular meshwork (TM) and configuration of collector channels (CC) by high-resolution optical coherence tomography (HR-OCT) induced by Schlemm's canal (SC) dilation. Methods: The anterior segments of two human eyes were divided into four quadrants. One end of a specially designed cannula was placed in SC and the other end connected to a perfusion reservoir. HR-OCT provided three-dimensional (3D) volumetric and two-dimensional (2D) cross-sectional imaging permitting assessment of the biomechanical properties of the TM. A large fluid bolus was introduced into SC. Same-sample, pre and post deformation and disruption of SC and CC lumen areas were analyzed. Results: Morphologic 3D reconstructions documented pressure-dependent changes in lumen dimension of SC, CC, and circumferential intrascleral channels. 2D imaging established volumetric stress-strain curves (elastance curves) of the TM in quadrants. The curves of TM elastance shift to the right with an increase in pressure-dependent steady-state SC area. After a bolus disruption, the SC area increased, while the CC area decreased. Conclusion: Our experimental setup permits the study of the biomechanical properties of TM by examining elastance, which differs segmentally and is altered by mechanical expansion of SC by a fluid bolus. The study may shed light on mechanisms of intraocular pressure control of some glaucoma surgery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available