Journal
TOXICS
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/toxics9020030
Keywords
silver nanoparticles; contextual memory; accumulation in brain; biodistribution; hippocampus; cerebellum; cortex; neutron activation analysis; CA2; fear
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Funding
- Russian Foundation for Basic Research [18-32-20197]
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The study revealed that prolonged administration of silver nanoparticles to mice can lead to memory impairments, mainly through the accumulation of silver in the brain, hippocampus, cerebellum, and cortex, causin disturbance of hippocampal cell integrity.
The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.
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