Aspirin Allergy-Induced Thrombocytopenia: A Case Report

Aspirin is clinically widely used to inhibit platelet aggregation after coronary intervention. Herein we describe a case of aspirin-induced thrombocytopenia that may be related to allergy to aspirin. A 47-year-old man developed a delayed hypersensitivity reaction to aspirin, with pruritus, purpura and thrombocytopenia, increased peripheral blood eosinophils and enlarged inguinal lymph node. All the symptoms disappeared in 2 years after stopping aspirin. Aspirin-induced thrombocytopenia related to allergy is rarely reported. Aspirin hypersensitivity should be taken into consideration in case of unexplained thrombocytopenia in patients taking aspirin. Aspirin allergy-induced thrombocytopenia may involve both aspirin related IgG and IgE antibodies.

Automated summary

Aspirin-induced thrombocytopenia related to allergy is rarely reported. Symptoms of aspirin allergy included pruritus, purpura, thrombocytopenia, increased eosinophils, and lymph node enlargement. Discontinuation of aspirin led to resolution of symptoms in this case.