Related references
Note: Only part of the references are listed.Modeling Alzheimer's disease with iPSC-derived brain cells
Jay Penney et al.
MOLECULAR PSYCHIATRY (2020)
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons
Rik van der Kant et al.
CELL STEM CELL (2019)
CRISPResso2 provides accurate and rapid genome editing sequence analysis
Kendell Clement et al.
NATURE BIOTECHNOLOGY (2019)
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al.
NATURE GENETICS (2019)
The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics
Arne De Roeck et al.
ACTA NEUROPATHOLOGICA (2019)
Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis
Sarah E. Sullivan et al.
HUMAN MOLECULAR GENETICS (2019)
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Iris E. Jansen et al.
NATURE GENETICS (2019)
Neural Lineage Differentiation From Pluripotent Stem Cells to Mimic Human Brain Tissues
Yean Ju Hong et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid- clearance in human astrocytes
Lauren K. Fong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types
Yuan-Ta Lin et al.
NEURON (2018)
The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons
Dmitry A. Ovchinnikov et al.
STEM CELL REPORTS (2018)
Modeling amyloid beta and tau pathology in human cerebral organoids
Cesar Gonzalez et al.
MOLECULAR PSYCHIATRY (2018)
Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
Jacqueline P. Robbins et al.
FRONTIERS IN NEUROSCIENCE (2018)
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level
Garmen Yuen et al.
NUCLEIC ACIDS RESEARCH (2017)
Dosage-sensitive genes in evolution and disease
Alan M. Rice et al.
BMC BIOLOGY (2017)
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
Ivan Carcamo-Orive et al.
CELL STEM CELL (2017)
Induced Pluripotent Stem Cells Meet Genome Editing
Dirk Hockemeyer et al.
CELL STEM CELL (2016)
Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
Mihaela Pertea et al.
NATURE PROTOCOLS (2016)
Non-coding genetic variants in human disease
Feng Zhang et al.
HUMAN MOLECULAR GENETICS (2015)
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Benjamin P. Kleinstiver et al.
NATURE (2015)
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
Stacy Steinberg et al.
NATURE GENETICS (2015)
APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons
Steven Moore et al.
CELL REPORTS (2015)
Development and Applications of CRISPR-Cas9 for Genome Engineering
Patrick D. Hsu et al.
CELL (2014)
An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells
Federico Gonzalez et al.
CELL STEM CELL (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
GENOME BIOLOGY (2014)
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
F. Ann Ran et al.
CELL (2013)
Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
Takayuki Kondo et al.
CELL STEM CELL (2013)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Vikram Pattanayak et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Jean-Charles Lambert et al.
NATURE GENETICS (2013)
Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
Yingsha Zhang et al.
NEURON (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Snakemake-a scalable bioinformatics workflow engine
Johannes Koester et al.
BIOINFORMATICS (2012)
Alzheimer Mechanisms and Therapeutic Strategies
Yadong Huang et al.
CELL (2012)
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
Mason A. Israel et al.
NATURE (2012)
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
Yichen Shi et al.
NATURE NEUROSCIENCE (2012)
Neuropathological Alterations in Alzheimer Disease
Alberto Serrano-Pozo et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)
Characterising and Predicting Haploinsufficiency in the Human Genome
Ni Huang et al.
PLOS GENETICS (2010)
Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease
Xin Wang et al.
JOURNAL OF NEUROSCIENCE (2008)
Bax-inhibiting peptides derived from Ku70 and cell-penetrating pentapeptides
J. A. Gomez et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
Kristel Sleegers et al.
BRAIN (2006)
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
A Rovelet-Lecrux et al.
NATURE GENETICS (2006)
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia
C Hetz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Bcl-2-family proteins and the role of mitochondria in apoptosis
T Kuwana et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death
MD Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria
YB Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis
F Relaix et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Share Paper
