Journal
JOURNAL OF HEPATOCELLULAR CARCINOMA
Volume 8, Issue -, Pages 23-33Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JHC.S286213
Keywords
hepatocellular carcinoma; AFP-negative; GLR; prognosis; early-recurrence
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Funding
- National Key Sci-Tech Special Project of China [2018ZX10302207]
- National Natural Science Foundation of China [81772923]
- Science and Technology Planning Project of Guilin [20190218-1]
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This study retrospectively analyzed clinicopathological data of 606 HCC patients who underwent radical resection, focusing on the potential of gamma-glutamyl transpeptidase to lymphocyte count ratio (GLR) as an indicator for early recurrence monitoring and prognosis evaluation. GLR was found to be associated with early recurrence and potentially predicting longer disease-free survival and overall survival in AFP-negative HCC patients after surgery.
Background: Currently, there is still a lack of effective biomarkers for the recurrence monitoring and survival prognosis assessment of hepatocellular carcinoma (HCC) patients with alpha-fetoprotein (AFP)-negative (<= 20 ng/mL) after radical resection. Methods: The clinicopathological data of 606 patients (303 in the AFP-negative group and 303 in the AFP-positive group) who underwent radical resection of HCC were analyzed retrospectively. Results: The gamma-glutamyl transpeptidase to lymphocyte count ratio (GLR) of patients in the AFP-negative group was lower than that in the AFP-positive group (p <0.001). The GLR level of the early-recurrence group was higher than that of the non-early-recurrence group (p =0.003). GLR had fair accuracy in predicting the early-recurrence of HCC patients [c-index=0.654 (95% CI=0.606-0.702); AUC=0.681 (95% CI=0.625-0.733)]. Univariate analysis showed that patients with tumor size <5 cm, no microvascular invasion, single tumor, no metastasis, BCLC stage 0-A, no recurrence, and GLR <= 45.0 had longer disease-free survival (DFS) and overall survival (OS) among AFP-negative HCC patients. In addition, multivariate Cox proportional hazards regression analysis showed that tumor size <5 cm (p =0.003), no recurrence (p <0.001), and GLR <45.0 (p <0.001) were independent predictors of longer OS. Conclusion: GLR may be a potential indicator for early recurrence monitoring and prognosis evaluation in HCC patients with AFP-negative after radical resection.
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