Are Sarcopenia and Cognitive Dysfunction Comorbid after Stroke in the Context of Brain-Muscle Crosstalk?

Stroke is a leading cause of death and disability and is responsible for a significant economic burden. Sarcopenia and cognitive dysfunction are common consequences of stroke, but there is less awareness of the concurrency of these conditions. In addition, few reviews are available to guide clinicians and researchers on how to approach sarcopenia and cognitive dysfunction as comorbidities after stroke, including how to assess and manage them and implement interventions to improve health outcomes. This review synthesises current knowledge about the relationship between post-stroke sarcopenia and cognitive dysfunction, including the physiological pathways, assessment tools, and interventions involved.

Automated summary

Stroke is a common cause of death and disability, often leading to sarcopenia and cognitive dysfunction as common consequences. There is a lack of awareness and guidance for clinicians and researchers on how to address sarcopenia and cognitive dysfunction as comorbidities after stroke. This review synthesises current knowledge on the relationship between post-stroke sarcopenia and cognitive dysfunction, including physiological pathways, assessment tools, and interventions.