Journal
CURRENT OPINION IN ELECTROCHEMISTRY
Volume 28, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.coelec.2021.100725
Keywords
Electrochemiluminescence (ECL); Immunoassay; Multiple-signals; Ratiometric ECL; Multiplex immunoassay; ECL imaging
Funding
- National Key Research and Development Program of China [2016YFA0201300]
- National Natural Science Foundation of China [22004116, 21804127, 21874126]
- CAS-VPST Silk Road Science Fund [GJHZ202125]
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This review summarizes recent advances in ECL strategies with multiple-signal outputs, including ratiometric ECL, ECL multiplex immunoassay (MIA), and ECL imaging, discussing their signal generation strategies and applications in immunoassays. Challenges and prospects in this field are also addressed.
Electrochemiluminescence (ECL) has been widely applied in immunoassays because of low background, high sensitivity, and excellent spatiotemporal controllability. In order to meet the increasing demand for high efficiency and accuracy of immunoassays in complex conditions, considerable efforts have been devoted to ECL strategies with multiple-signal outputs. In this short review, we summarize the recent advances of ECL strategies based on multiple-signal outputs, which includes ratiometric ECL, ECL multiplex immunoassay (MIA), and ECL imaging. Their signal generation strategies and analysis applications for immunoassay are discussed in detail. Moreover, the challenges and prospects in this field from us are addressed.
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