Journal
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
Volume 41, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colcom.2021.100386
Keywords
Flower micelles; Against aggregation; Stability; Drug delivery
Funding
- National Natural Science Funds for Distinguished Young Scholars [51625305]
- National Natural Science Foundation of China [51273187, 21474097]
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Polymeric micelles, especially flower micelles with a unique PEG shell, are more stable in the presence of serum and salt compared to traditional micelles. This stability is crucial for drug delivery, as it prevents aggregation and ensures efficient delivery of therapeutic agents to the target area.
Polymeric micelles are promising vehicles for drug delivery these years. The stability of micelles in blood system is very important for the encapsulated therapeutic agents reaching the targeting area. However, generally, micelles are not stable in the presence of proteins and ions after being injected intravenously. The topology of polymer chain on the surface of micelles plays a key role on the stability of micelles. Here we have prepared flower micelles and the traditional micelles via self-assembly of triblock and diblock copolymer of polyethylene glycol (PEG) and poly(epsilon-caprolactone) (PCL) in water. The special PEG shell of flower micelles prevents micelles from ions and proteins, which endows the micelles with the ability to resist aggregation. The experiment results show that flower micelles are much more stable in the presence of serum and salt than traditional micelles, which indicates these micelles would be promising in drug delivery in the future.
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