Journal
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
Volume 41, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colcom.2021.100378
Keywords
Polymeric micelles; Hofmeister; Molecular interactions; Macrophage; Nitric oxide
Funding
- FAPESB (Fundacao de Amparo a Pesquisa do Estado da Bahia)
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This study investigated the colloid phenomena between 3-methyl-5-phenyl-pyrazoline-1-(S-benzyldithiocarbazate) (DTC) and Pluronic F127 through fluorescence measurements, revealing that the DTC-based micellar system is not cytotoxic to Swiss mice peritoneal macrophages and induces nitric oxide (NO) production in these cells.
Nitrogen and sulfur-containing heterocyclic compounds as pyrazole and dithiocarbazate have historically been reported as sources of therapeutic agents. This work reports by fluorescence measurements the colloid phenomena between the 3-methyl-5-phenyl-pyrazoline-1-(S-benzyldithiocarbazate) (DTC) and Pluronic F127, a copolymer that has a tendency to self-assemble into micelles in aqueous medium. The cytotoxicity of the DTCbased micellar system was evaluated in Swiss mice peritoneal macrophages, and the production of nitric oxide (NO) by these cells was also analyzed in vitro and molecular docking analysis. The DTC-based micellar system prevents the DTC decomposition and increases solubility. The Hofmeister ions modulate DTC-micelle interactions. The DTC-based micellar system is not cytotoxic to Swiss mice peritoneal macrophages and induces the production of NO by these cells. These findings make the DTC-based micellar system of great interest in health/ disease processes, since its immunomodulatory action on the macrophages may be tools on further studies for the development of novel microbicide or anti-inflammatory drugs.
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