Journal
FRONTIERS IN VETERINARY SCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2021.647189
Keywords
FIP; coronavirus; 5-aminolevulinic acid; antiviral drug; cat
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Funding
- Neopharma Japan Co., Ltd.
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The study found that 5-ALA can effectively inhibit FIPV infection, making it a potential drug for treating and preventing FIPV infection.
Feline infectious peritonitis (FIP) is a life-threatening infectious disease of cats caused by virulent feline coronavirus (FIP virus: FIPV). For the treatment of FIP, several effective antivirals were recently reported, but many of these are not available for practical use. 5-amino levulinic acid (5-ALA) is a low-molecular-weight amino acid synthesized in plant and animal cells. 5-ALA can be synthesized in a large amount, and it is widely applied in the medical and agricultural fields. We hypothesized that 5-ALA inhibits FIPV infection. Therefore, we evaluated its antiviral activity against FIPV in felis catus whole fetus-4 cells and feline primary macrophages. FIPV infection was significantly inhibited by 250 mu M 5-ALA. Our study suggested that 5-ALA is applicable for the treatment and prevention of FIPV infection.
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