Journal
ACS OMEGA
Volume 6, Issue 5, Pages 3517-3524Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c04643
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Funding
- Advanced Research Center for Green Materials Science and Technology from The Featured Area Research Center Program within Ministry of Education [107L9006]
- Ministry of Science and Technology in Taiwan [MOST 107-3017-F-002-001, 106-2221-E-002-166]
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A simple one-step coating method has been developed to inhibit the adhesion of L929 cells and significantly reduce protein adsorption, with a positive correlation to increasing coating time, surface hydrophilicity, and film thickness. The coating exhibits resistance against harsh sterilization conditions and stability for long-term storage in phosphate-buffered saline, making it applicable for the manufacture of medical devices.
Antifouling treatment is critical to certain biomedical devices for their functions and patients' life. Facial, versatile, and universal coating methods to conjugate antifouling materials on a wide variety of biomaterials are beneficial for the fabrication of low-fouling biomedical devices. We developed a simple one-step coating method for surface conjugation of zwitterionic poly(sulfobetaine) via deposition of self-polymerized pyrogallol (PG). Poly(pyrogallol) could deposit copolymers of sulfobetaine methacrylate and aminoethyl methacrylate (pSBAE) on various biomaterials. pSBAE coatings inhibited as high as 99.8% of the adhesion of L929 cells and reduced protein adsorption significantly. The resistance against L929 cell adhesion was increased with increasing coating time and was positively correlated with the surface hydrophilicity and film thickness. Such a coating was robust to resist harsh sterilization conditions and stable for long-term storage in phosphate-buffered saline. We expect that the simple low-fouling pSBAE coating is applicable to the manufacture of medical devices.
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