Journal
ANTIBIOTICS-BASEL
Volume 10, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics10020130
Keywords
bacteriophage (phage); hydrogel; multidrug-resistant bacteria; formulation; efficacy; safety; stability
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This paper reviews the formulation of phage-delivering hydrogels for orthopedic implant-associated bone infection, catheter-associated urinary tract infection, and trauma-associated wound infection, focusing on the preparation methods, stability, efficacy, and safety of hydrogels as phage carriers.
Antibiotic resistance remains as an unresolved global challenge in the health care system, posing serious threats to global health. As an alternative to antibiotics, bacteriophage (phage) therapy is rising as a key to combating antibiotic-resistant bacterial infections. In order to deliver a phage to the site of infection, hydrogels have been formulated to incorporate phages, owing to its favorable characteristics in delivering biological molecules. This paper reviews the formulation of phage-delivering hydrogels for orthopedic implant-associated bone infection, catheter-associated urinary tract infection and trauma-associated wound infection, with a focus on the preparation methods, stability, efficacy and safety of hydrogels as phage carriers.
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