Journal
FRONTIERS IN MEDICINE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2021.585358
Keywords
SARS-CoV-2; population bottleneck; intra-host variation; human to human transmission; evolution
Categories
Funding
- National Key Research and Development Program of China [2018YFC1200100, 2018ZX10301403, 2018YFC1311900]
- emergency grants for prevention and control of SARS-CoV-2 of Ministry of Science and Technology [2020YFC0841400]
- Guangdong province [2020B111107001, 2020B111108001, 2020B111109001, 2018B020207013, 2020B111112003]
- Guangdong Province Basic and Applied Basic Research Fund [2020A1515010911]
- Guangzhou Medical University High-level University Innovation Team Training Program (Guangzhou Medical University released [2017]) [159]
- Shenzhen Municipal Government of China Peacock Plan [KQTD2015033017150531]
- China National GeneBank (CNGB)
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The study found active viral replication in the respiratory tract of COVID-19 patients and genetically distinct viruses within the same host. Comparisons between viral populations among patients revealed a narrow transmission bottleneck within the same households, indicating a dominant role of stochastic dynamics in both inter-host and intra-host evolutions.
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
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